VirEOS Publications

Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that bind a conserved membrane proximal epitope of the spike.

Sieglinde De Cae, Inge Van Molle, Loes van Schie, Sophie R. Shoemaker, Julie Deckers, Nincy Debeuf, Sahine Lameire, Wim Nerinckx, Kenny Roose, Daria Fijalkowska, Simon Devos, Anne-Sophie Desmet, Jackeline Cecilia Zavala Marchan, Toon Venneman, Koen Sedeyn, Marlies Ballegeer, Manon Vanheerswynghels, Caroline De Wolf, Hans Demol, Pieter Vanhaverbeke, Gholamreza Hassanzadeh Ghassabeh, Chiara Lonigro, Viki Bockstal, Manuela Rinaldi, Rana Abdelnabi, Johan Neyts, Susan Marqusee, Bart N. Lambrecht, Nico Callewaert, Han Remaut, Xavier Saelens, Bert Schepens.

Single-molecule analysis of SARS-CoV-2 binding to C-type lectin receptors

J.D. Simpson, A. Ray, C. Marcon, R. dos Santos Natividade, G. Mohammad Dorrazehi, K. Durlet, M. Koehler, D. Alsteens

Single-molecule investigation of the binding interface stability of SARS-CoV-2 variants with ACE2"A.

Ray, T. T. Min Tran, R. d. S. Natividade, R.A. Moreira, J.D. Simpson, D. Mohammed, M. Koehler, S. J.L Petitjean, Q. Zhang, F. Bureau, L. Gillet, A.B. Poma,D. Alsteens

Integrating artificial intelligence-based epitope prediction in a SARS-CoV-2 antibody discovery pipeline: caution is warranted.

Acar DD, Witkowski W, Wejda M, Wei R, Desmet T, Schepens B, De Cae S, Sedeyn K, Eeckhaut H, Fijalkowska D, Roose K, Vanmarcke S, Poupon A, Jochmans D, Zhang X, Abdelnabi R, Foo CS, Weynand B, Reiter D, Callewaert N, Remaut H, Neyts J, Saelens X, Gerlo S, Vandekerckhove L.

YF17D-based vaccines - standing on the shoulders of a giant.

Sanchez-Felipe L, Alpizar YA, Ma J, Coelmont L, Dallmeier K.

Antigenic imprinting dominates humoral responses to new variants of SARS-CoV-2 in a hamster model of COVID-19

Joran Degryse, Elke Maas, Ria Lassaunière, Katrien Geerts, Yana Kumpanenko, Birgit Weynand, Piet Maes, Johan Neyts, Hendrik Jan Thibaut, Yeranddy A. Alpizar, Kai Dallmeier

Repeated COVID-19 mRNA-based vaccination contributes to SARS-CoV-2 neutralizing antibody responses in the mucosa

Declercq J, Gerlo S, Van Nevel S, De Ruyck N, Holtappels G, Delesie L, Tobback E, Lammens I, Gerebtsov N, Sedeyn K, Saelens X, Lambrecht BN, Gevaert P, Vandekerckhove L, Vanhee S.

Multiplexed multicolor antiviral assay amenable for high-throughput research.

Li LH, Chiu W, Huang YA, Rasulova M, Vercruysse T, Thibaut HJ, Ter Horst S, Rocha-Pereira J, Vanhoof G, Borrenberghs D, Goethals O, Kaptein SJF, Leyssen P, Neyts J, Dallmeier K.

Polyfunctional immunity and transcriptional imprint associated with protection by chimeric live-attenuated Zika virus vaccine in non-human primates.

Ji Ma, Bert Malengier-Devlies, Babs Verstrepen, Yeranddy Alpizar Aquiar, Thomas Vercruysse, Mahadesh Javarappa, Lorena Sanchez-Felipe, Gerrit Koopmans, Natasja de Groot, Patrick Matthys, Johan Neyts, Ernst Verschoor, Lotte Coelmont, Hendrik Jan Thibaut, Johan Van Weyenbergh, Kai Dallmeier

Involvement of paraspeckle components in viral infections.

Milcamps R, Michiels T.

MX2 forms nucleoporin-comprising cytoplasmic biomolecular condensates that lure viral capsids.

Moschonas GD, Delhaye L, Cooreman R, Hüsers F, Bhat A, Stylianidou Z, De Bousser E, De Pryck L, Grzesik H, De Sutter D, Parthoens E, De Smet AS, Maciejczuk A, Lippens S, Callewaert N, Vandekerckhove L, Debyser Z, Sodeik B, Eyckerman S, Saelens X.

GLP-1R agonist therapy and vaccine response: Neglected implications.

van Niekerk G, Coelmont L, Alpizar YA, Kelchtermans L, Broeckhoven E, Dallmeier K.

Cholecystokinin and gastrin as immune modulating hormones: Implications and applications.

van Niekerk G, Kelchtermans L, Broeckhoven E, Coelmont L, Alpizar YA, Dallmeier K.

Thymidine kinase-expressing yellow fever 17D reporter virus facilitates prodrug activation and bioorthogonal labelling of infected cells.

Michael B. Yakass, Sander Jansen, Viktor Lemmens, Lorena Sanchez-Felipe, Johan Neyts, Nathan W. Luedtke, Osbourne Quaye, Kai Dallmeier

SeParate: multiway fluorescence-activated droplet sorting based on integration of serial and parallel triaging concepts.

Verbist W, Breukers J, Sharma S, Rutten I, Gerstmans H, Coelmont L, Dal Dosso F, Dallmeier K, Lammertyn J.

YF17D-vectored Ebola vaccine candidate protects mice against lethal surrogate Ebola and yellow fever virus challenge.

Lemmens V, Kelchtermans L, Debaveye S, Chiu W, Vercruysse T, Ma J, Thibaut HJ, Neyts J, Sanchez-Felipe L, Dallmeier K.

Regulation of viral RNA-dependent RNA polymerases by phosphorylation

Duflos C, Michiels T

Heparin-induced allosteric changes in SARS-CoV-2 spike protein facilitate ACE2 binding and viral entry

S.J.L. Petitjean, S. Eeckhout, M. Delguste, Q. Zhang, K. Durlet, D. Alsteens

Palaeoserology - teeth put into ancient plagues and pandemics.

Dallmeier K.

Development of SARS-CoV2 humoral response including neutralizing antibodies is not sufficient to protect patients against fatal infection.

Choteau M, Scohy A, Messe S, Luyckx M, Dechamps M, Montiel V, Yombi JC, Gruson D, Limaye N, Michiels T, Dumoutier L.

Live-attenuated YF17D-vectored COVID-19 vaccine protects from lethal yellow fever virus infection in mouse and hamster models.

Ma J, Yakass MB, Jansen S, Malengier-Devlies B, Van Looveren D, Sanchez-Felipe L, Vercruysse T, Weynand B, Javarappa MPA, Quaye O, Matthys P, Roskams T, Neyts J, Thibaut HJ, Dallmeier K.

Updated vaccine protects against SARS-CoV-2 variants including Omicron (B.1.1.529) and prevents transmission in hamsters.

Sharma S, Vercruysse T, Sanchez-Felipe L, Kerstens W, Rasulova M, Bervoets L, De Keyzer C, Abdelnabi R, Foo CS, Lemmens V, Van Looveren D, Maes P, Baele G, Weynand B, Lemey P, Neyts J, Thibaut HJ, Dallmeier K.

Cov2MS: An Automated and Quantitative Matrix-Independent Assay for Mass Spectrometric Measurement of SARS-CoV-2 Nucleocapsid Protein.

Van Puyvelde B, Van Uytfanghe K, Van Oudenhove L, Gabriels R, Van Royen T, Matthys A, Razavi M, Yip R, Pearson T, Drouin N, Claereboudt J, Foley D, Wardle R, Wyndham K, Hankemeier T, Jones D, Saelens X, Martens G, Stove CP, Deforce D, Martens L, Vissers JPC, Anderson NL, Dhaenens M.

Cardiovirus leader proteins retarget RSK kinases toward alternative substrates to perturb nucleocytoplasmic traffic.

Lizcano-Perret B, Lardinois C, Wavreil F, Hauchamps P, Herinckx G, Sorgeloos F, Vertommen D, Gatto L, Michiels T.